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9b), ETC complex expression (CIII, CI

The sulfhydryl side chains of the cysteine residues of two glutathione molecules form a disulfide bond (GSSG) during the course of being oxidized in reactions with various oxides and peroxides in cells

If the extent of tolerance to the challenge opioid drug is similar to the induction opioid then cross-tolerance is symmetric, if not it is asymmetric

Their GSTO1 inhibitory activity was further confirmed by a competitive binding assay

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Adverse effects were linked to the dosage of the drug, suggesting patients may be able to avoid side effects with lower doses